Parmar, Tejasvi H. published the artcileSynthesis of novel drug-like small molecules library based on 1H-benzo[d]imidazole, Quality Control of 915763-60-9, the publication is Australian Journal of Chemistry (2022), 75(4), 276-284, database is CAplus.
A series of novel ‘drug-like’ small mols. based on 1H-benzo[d]imidazole derivatives bearing furan-2-yl, 4-piperidine and 5-aryl/aminoaryl substitutions were designed and synthesized. The key intermediate tert-butyl-4-(5-bromo-2-(furan-2-yl)-1H-benzo[d]imidazol-1-yl)piperidine-1-carboxylate was synthesized via sequential reaction starting from 4-bromo-1-fluoro-2-nitrobenzene. The 5-aryl-substituted mol. library was generated via Suzuki-Miyaura coupling of the key intermediate with various boronic acids while Buchwald coupling with various anilines generated the second mol. library of tert-butyl-4-(2-(furan-2-yl)-5-(arylamino)-1H -benzo[d]imidazol-1-yl)piperidine-1-carboxylates. The structures of all the newly synthesized compounds were confirmed by spectral anal. The optimized procedure gives easy access to two new mol. libraries of 1H-benzo[d]imidazoles with operational simplicity and good yield.
Australian Journal of Chemistry published new progress about 915763-60-9. 915763-60-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is (3-Chloro-5-cyanophenyl)boronic acid, and the molecular formula is C7H5BClNO2, Quality Control of 915763-60-9.
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