Ramana, P. Venkata published the artcileSynthesis of 1,2,3-triazole substituted isoxazoles via copper(I) catalyzed cycloaddition, Application In Synthesis of 3919-74-2, the publication is Journal of Heterocyclic Chemistry (2012), 49(3), 621-627, database is CAplus.
The synthesis of a series of 3,5-disubstituted isoxazole-4-carboxylic esters containing N-substituted 1,2,3-triazoles starting from various benzaldehydes was reported. Initially, the benzaldehydes underwent oximation with NH2OH.HSO4. Later, chlorination followed by condensation with AcCH2CO2Me and hydrolysis of the resulting ester afforded the resp. carboxylic acids, which on chlorination with PCl5 gave the corresponding acid chlorides. Subsequent propargylation gave propargylic esters, which led to the title compounds on click reaction.
Journal of Heterocyclic Chemistry published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Application In Synthesis of 3919-74-2.
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