Ramana, Parikibanda Venkata published the artcileSynthesis of dihydrooxazoylarylisoxazoles by conventional and under microwave conditions, Recommanded Product: 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, the publication is European Journal of Chemistry (2011), 2(3), 300-307, database is CAplus.
The synthesis of series of 3-aryl-4-dihydrooxazolyl-5-Me trisubstituted isoxazoles I(R1 = R2 = H, Cl, R1 = H, R2 = Cl, R1 = Cl, R2 = F; R3 = R4 = H, Me, R3 = Me, iPr, R4 = H ) is reported, both under thermal and microwave conditions starting from various benzaldehydes. Benzaldehydes undergo oximation with hydroxylamine hydrosulfate to provide oximes that upon chlorination, followed by condensation with methylacetoacetate, resulted in the formation of esters. Hydrolysis of the esters to acids followed by treatment with PCl5, resulted in the formation of acid chlorides that upon reaction with hydroxyamines, gave N-β-hydoxyalkyl amides. These on further reaction with SOCl2, followed by cyclization with 2 N NaOH provided oxazoline substituted isoxazoles in good yields. The conversion acidchlorides to isoxazoles was also achieved by microwave irradiation in moderate to excellent yields, with shorter reaction times compared to the conventional thermal method.
European Journal of Chemistry published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Recommanded Product: 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics