Rueger, Carla published the artcileNew derivatives of 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-ones with anticholinergic activity, Safety of 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, the publication is Pharmazie (1990), 45(8), 555-9, database is CAplus.
Condensation of 4,2-R(O2N)C6H3Cl (R = H, Cl) with 2-H2NC6H4CO2H gave 2-[4,2-R(O2N)C6H3NH]C6H4CO2H (same R). The reduction of the latter gave 2-[4,2-R(H2N)C6H3NH]C6H4CO2H which upon cyclocondensation gave 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and its 8-chloro derivative The latter products were acylated or methylated and acylated to give 5-acyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-ones I (R = H, Cl; R1 = H, Me; R2 = Cl, CH2Cl, etc.); the I thus obtained were aminated to give I [R = H, Cl; R1 = H, Me; R2 = N(CH2CH2OH)2, NMe(CH2CH2OH), etc.] (II). The ulcer-inhibiting activity of II was postulated; II (R = Cl; R1 = H; R2 = N(CH2CH2)H)].HCl, i.e. AWD 26-06, is selected for clin. evaluation (no data). II thus prepared differ from other tricyclic psychopharmaceuticals in their lipid solubility and hence have no effect as central nervous system agents.
Pharmazie published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, Safety of 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics