Somawardhana, C. W. published the artcileSynthesis of 2-[123I and 124I]-iodoisonicotinic acid hydrazide-potential radiotracers for tuberculosis, SDS of cas: 6313-54-8, the publication is Applied Radiation and Isotopes (1991), 42(3), 215-20, database is CAplus and MEDLINE.
The radiochem. syntheses of Me 2-[123I]-iodoisonicotinate, 2-[123I]-iodoisonicotinic acid hydrazide (I) and 2-[124I]-iodoisonicotinic acid hydrazide was accomplished. Iodine-123 was incorporated in the Me ester mol. by an exchange reaction in glacial acetic acid. The average efficiency of iodine exchange reaction was (92.6%). This radiotracer was extracted with ether and the solvent was evaporated The residue was re-dissolved in anhydrous ethanol and treated with hydrazine under anhydrous conditions to obtain I. The overall radiochem. yield was 69%. Biodistribution data of both radio-tracers in male Sprague-Dawley rats were collected. This is the first report of SPECT radiopharmaceuticals which may be useful for differential diagnosis of intracranial masses (tuberculoma vs. glioma), and CNS tuberculosis in immunosuppressed subjects.
Applied Radiation and Isotopes published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C9H10O4, SDS of cas: 6313-54-8.
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