Tarakhovskii, M. L. published the artcileAnticholinesterase activity and toxicity of some phosphonate esters containing a trichloromethyl group, Formula: C5H10Cl3O3P, the publication is Fiziologicheski Aktivnye Veshchestva (1976), 33-6, database is CAplus.
Of 11 phosphonic acid esters tested [ROP:O(OR1)R2], the 2 compds, where R = Et, R1 = (CH2)4CCl3, R2 = Me and where R = R1 = Et, R2 = CCl3 had the greatest anticholinesterase activity, inhibiting the enzyme 50% at 8.3 × 10-7 and 7.6 × 10-6 mol/L, resp. The compound where R = R1 = Et, R2 = Me had no anticholinesterase activity and the remaining compounds inhibited the enzyme at concentrations ranging from 5.75 × 10-5 to 6.5 × 10-1 mol/L. The i.p. LD50 values in mice ranged from 720 to 2240 mg/kg, the most active anticholinesterase having the greatest toxicity and the inactive compound having the least. These compounds were less toxic than some presently used in medical practice.
Fiziologicheski Aktivnye Veshchestva published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C10H11NO4, Formula: C5H10Cl3O3P.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics