Thakare, Prashant published the artcileSynthesis and biological evaluation of novel 4-(6-substituted quinolin-4-yl)-N-aryl thiazol-2-amine derivatives as potential antimicrobial agents, HPLC of Formula: 3696-23-9, the publication is Journal of Heterocyclic Chemistry (2021), 58(9), 1867-1877, database is CAplus.
Cyclocondensation reaction of 4-(2-bromoacetyl)quinolin-1-ium bromide with substituted arylthiourea, afforded 4-(6-substituted quinolin-4-yl)-N-aryl/pyridyl thiazol-2-amine I (R = H, Cl, F, Br; Ar = C6H4NH2, 2-pyridylamine, 4-MeC6H4NH2, etc.). These newly synthesized derivatives were evaluated for in vitro antibacterial activity against Escherichia coli (NCIM 2574), Proteus mirabilis (NCIM 2388) (Gram-neg. strains), Bacillus subtilis (NCIM 2063), Staphylococcus albus (NCIM 2178) (Gram-pos. strains) and in vitro antifungal activity against Aspergillus niger (ATCC 504) and Candida albicans (NCIM 3100). Most of the compounds showed moderate to good antibacterial activity against S. albus. Ten derivatives showed moderate to good activity against A. niger. N-[4-(Quinolin-4-yl)-1,3-thiazol-2-yl]pyridin-2-amine presented comparable activity against A. niger with respect to standard drug Rouconazole.
Journal of Heterocyclic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C16H12O, HPLC of Formula: 3696-23-9.
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