Wang, Fuxiang published the artcileSynthesis of clozapine, Related Products of chlorides-buliding-blocks, the publication is Zhongguo Yiyao Gongye Zazhi (2013), 44(10), 969-971, database is CAplus.
Compounds 2,5-dichloronitrobenzene and anthranilic acid were reacted in the presence of potassium carbonate with DMF as solvent to produce 2-(4-chloro-2-nitroanilino)benzoic acid, which was reduced to 2-(2-amino-4-chloroanilino)benzoic acid (5) by hydrazine hydrate and FeCl3· 6H2O. Catalyzed by polyphosphoric acid in xylene, compound 5 was cyclized into 8-chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one, which was coupled with N-methylpiperazine in the presence of titanium tetrachloride to give clozapine. The overall yield was 43%, based on 2,5-dichloronitrobenzene.
Zhongguo Yiyao Gongye Zazhi published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C24H20Ge, Related Products of chlorides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics