Chen, Zhi-wei published the artcileSynthesis of 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarbonyl chloride, Application of 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, the publication is Zhongguo Xiandai Yingyong Yaoxue (2008), 25(4), 308-309, database is CAplus.
A method for the synthesis of the title compound [i.e., 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarbonyl chloride] is reported here. The synthesis of the target compound was achieved by a synthetic sequence involving an oximation reaction, chlorination, cyclization, hydrolysis, acyl chlorination using 2-chloro-6-fluorobenzaldehyde as starting material. The structure was determined by IR, NMR, 13C-NMR, MS (overall yield 60.2%). This is a practical and low-cost synthetic route. The above-mentioned target compound is an intermediate for flucloxacillin [i.e., (2S,5R,6R)-6-[[[3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid].
Zhongguo Xiandai Yingyong Yaoxue published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Application of 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid.
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