Guo, Zhenbo published the artcileDesign, synthesis and evaluation of novel (S)-tryptamine derivatives containing an allyl group and an aryl sulfonamide unit as anticancer agents, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Bioorganic & Medicinal Chemistry Letters (2019), 29(9), 1133-1137, database is CAplus and MEDLINE.
A series of (S)-tryptamine derivatives containing an allyl group and an aryl sulfonamide unit, I (R = Ph, 3-Cl-4-FC6H3, 4-Br-2-ClC6H4, etc.) and II [R = Ph, 2,4,6-(Me2CH)3C6H2], were designed, synthesized and evaluated for their potential application as anticancer agents. The structures of the synthesized compounds were characterized by 1H NMR, 13C NMR and ESI-MS spectral analyses. The target compounds were evaluated for their in vitro cytotoxicity against HepG2, HeLa, CNE1 and A549 human cancer cell lines. Some of the synthesized compounds showed moderate to good anticancer activities against four selected cancer cell lines, among of which I [R = 2,4,6-(Me2CH)C6H2] (III) was found to be the most active analog possessing IC50 values 16.5-18.7 μM. Further mechanism studies revealed that compound III could significantly induce HepG2 cell cycle arrest at G1 phase, promote cell apoptosis, and inhibit the colony formation as well.
Bioorganic & Medicinal Chemistry Letters published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.
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