Kanno, Hideo published the artcileSynthesis and antihypertensive activity of 1,4-dihydropyridine derivatives with a 4-(disubstituted phenyl) ring and an aminoalkyl ester group: highly potent and long-lasting calcium antagonists, Quality Control of 116850-28-3, the publication is Chemical & Pharmaceutical Bulletin (1992), 40(8), 2049-54, database is CAplus and MEDLINE.
New 1,4-dihydropyridine derivatives I (R = Cl, F, NO2; R1, R2 = H, Cl, F, NO2; X = CH2, CMe2CH2), bearing a 4-(disubstituted phenyl) ring and an aminoethyl ester or an amino-2,2-dimethylpropyl ester, were synthesized and their antihypertensive activities were examined in normotensive rats and spontaneously hypertensive rats. The effects of Ph substituents and ester groups on the antihypertensive activity are discussed. Several compounds showed a more potent antihypertensive activity than nicardipine and most compounds had a longer duration of action. Among them, I (R = F, R1 = H, R2 = NO2, X = CMe2CH2).HCl showed highly potent and long-lasting activity and was selected as a candidate for further pharmacol. investigations.
Chemical & Pharmaceutical Bulletin published new progress about 116850-28-3. 116850-28-3 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzene, name is 2-Chloro-1-fluoro-3-methylbenzene, and the molecular formula is C7H6ClF, Quality Control of 116850-28-3.
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