Linghu, Xin published the artcileDevelopment of a Practical Synthesis of ERK Inhibitor GDC-0994, SDS of cas: 1263414-46-5, the publication is Organic Process Research & Development (2017), 21(3), 387-398, database is CAplus.
The process development of a synthetic route to manufacture ERK inhibitor GDC-0994, I, on multikilogram scale is reported herein. The API was prepared as the corresponding benzenesulfonate salt in 7 steps and 41% overall yield. The synthetic route features a biocatalytic asym. ketone reduction, a regioselective pyridone SN2 reaction, and a safe and scalable tungstate-catalyzed sulfide oxidation The end-game process involves a telescoped SNAr/desilylation/benzenesulfonate salt formation sequence. Finally, the development of the API crystallization allowed purging of process-related impurities, obtaining >99.5A% HPLC and >99% ee of the target mol.
Organic Process Research & Development published new progress about 1263414-46-5. 1263414-46-5 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Alkenyl,Benzene, name is 4-Chloro-3-fluorostyrene, and the molecular formula is C8H6ClF, SDS of cas: 1263414-46-5.
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