McConnell, Nicholas published the artcileSynthesis of Constrained Heterocycles Employing Two Post-Ugi Cyclization Methods for Rapid Library Generation with In Cellulo Activity, Quality Control of 6313-54-8, the publication is ChemistrySelect (2017), 2(35), 11821-11825, database is CAplus and MEDLINE.
An efficient method was developed for the synthesis of benzimidazole dual-heterocycles, e.g., I and quinoxalinone dual-heterocycles, e.g., II utilizing robust post-Ugi cyclization starting from carboxylic acids, isocyanides, benzaldehydes and N-Boc-1,2-phenylenediamine including Ugi-deprotection-cyclization methodol. Through mol. modeling it was shown that the developed compounds I and II were capable of binding to MDMX by exploiting a deep non-polar groove and a deep hydrophobic pocket on the protein. Addnl., the synthesized compounds I and II showed micromolar activity against pancreatic cancer cell line, supporting the therapeutic utility of these compounds
ChemistrySelect published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Quality Control of 6313-54-8.
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https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics