Miao, Qingqing published the artcileNear-Infrared Fluorescent Molecular Probe for Sensitive Imaging of Keloid, Safety of 2-Chlorotrityl chloride, the publication is Angewandte Chemie, International Edition (2018), 57(5), 1256-1260, database is CAplus and MEDLINE.
Early detection of skin diseases is imperative for their effective treatment. However, fluorescence mol. probes that allow this are rare. The first activatable near-IR (NIR) fluorescent mol. probe is reported for sensitive imaging of keloid cells, skin cells from abnormal scar fibrous lesions. As keloid cells have high expression levels of fibroblast activation protein-alpha (FAPα), the probe (FNP1) is designed to have a caged NIR dye and a FAPα-cleavable peptide substrate linked by a self-immolative segment. FNP1 can quickly and specifically turn on its fluorescence at 710 nm by 45-fold in the presence of FAPα, allowing it to effectively recognize keloid cells from normal skin cells. Integration of FNP1 with a simple microneedle-assisted topical application enables sensitive detection of keloid cells in metabolically-active human skin tissue with a theor. limit of detection down to 20 000 cells.
Angewandte Chemie, International Edition published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Safety of 2-Chlorotrityl chloride.
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https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics