Nasim, Muhammad Jawad published the artcilePronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria, SDS of cas: 620-20-2, the publication is New Journal of Chemistry (2019), 43(15), 6021-6031, database is CAplus.
Selenocyanates represent an interesting class of organic selenium compounds Due to their similarity with better known natural (iso-)thiocyanates, they promise high biol. activity and may also be metabolized to other reactive selenium species (RSeS), such as selenols, diselenides, and seleninic acids. Thirteen arylmethyl selenocyanates were synthesized and evaluated for potential antimicrobial, nematicidal, and cytotoxic activity. The compounds exhibit pronounced antimicrobial activity against various strains of Gram-pos. and Gram-neg. bacteria and yeasts, including multidrug resistant strains. The results obtained so far demonstrate that these arylmethyl selenocyanates are also non-mutagenic and have limited cytotoxicity against human cells. Here, benzyl selenocyanate represents the most active anti-ESKAPE agent, with potent activity against multidrug resistant MRSA strains (HEMSA 5) with a competitive MIC value of just 0.76 μg/mL (3.88 μM), whereas it exhibits low(er) cytotoxicity (IC50 = 31 μM) and no mutagenicity against mammalian cells. Due to this selective antimicrobial activity, aromatic selenocyanates may provide an interesting lead in the development of antimicrobial agents, particularly in the context of drug resistance.
New Journal of Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, SDS of cas: 620-20-2.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics