Shen, Chong published the artcileCatalytic Asymmetric Umpolung Allylation/2-Aza-Cope Rearrangement for the Construction of α-Tetrasubstituted α-Trifluoromethyl Homoallylic Amines, COA of Formula: C8H4ClF3O, the publication is Organic Letters (2019), 21(17), 6940-6945, database is CAplus and MEDLINE.
A general protocol for the preparation of enantioenriched α-tetrasubstituted α-trifluoromethyl homoallylic amines (R)-F3CCR(NH2)CH2CH:CHR1 (R = Ph, 4-ClC6H4, 2-naphthyl, etc., R1 = Ph, 3-MeC6H4, 2-thienyl, etc.) and (S)-F3CCH(NH2)CH2CH:CHR2 (R2 = Ph, 3-MeC6H4, 2-furyl, 6-quinolinyl, etc.) is disclosed. Despite the significant challenge in stereoselectivity control, Ir-catalyzed asym. cascade umpolung allylation/2-aza-Cope rearrangement of trifluoromethylated fluorenone imines with allylic carbonates was realized with excellent efficiency and remarkable stereoselectivity. These were enabled by the suitable protective imino moiety and an unexpectedly exclusive E-geometrical imine of the allylation intermediate. This methodol. is also applicable to facile access to chiral α-trisubstituted α-trifluoromethyl homoallylic amines in similarly high yield and stereoselectivity.
Organic Letters published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C13H9FO2, COA of Formula: C8H4ClF3O.
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