Wu, Shaotong published the artcileA stereo configuration-activity study of 3-iodo-4-(2-methylcyclohexyloxy)-6-phenethylpyridin-2(2H)-ones as potency inhibitors of HIV-1 variants, HPLC of Formula: 21286-54-4, the publication is Organic & Biomolecular Chemistry (2016), 14(4), 1413-1420, database is CAplus and MEDLINE.
3-Iodo-4-(2′-methylcyclohexyloxy)-6-phenethylpyridin-2(1H)-ones, as effective non-nucleoside reverse transcriptase inhibitors, were synthesized and resolved with different configurations. Biol. results revealed that the trans-racemate exhibited more potent activity than the cis-isomers. Noticeably, the trans-(S,S)-enantiomer turned out to be significantly more potent than its counterpart enantiomer against wild-type and double-mutant strains with high selectivity indexes.
Organic & Biomolecular Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C11H9NO3, HPLC of Formula: 21286-54-4.
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