Xu, Yanjun published the artcilePyridine derivatives(X): synthesis and herbicidal activities of 2-sec-butylamino-5-(2-aryloxy-4-pyridinyl)-4-yl)-1,3,4-thiadiazoles, Application of 2-Chloroisonicotinic acid, the publication is Nongyaoxue Xuebao (2007), 9(2), 189-192, database is CAplus.
A method for the synthesis of the title compounds [i.e., N-(1-methylpropyl)-5-[2-(phenoxy)-4-pyridinyl]-1,3,4-thiadiazol-2-amine derivatives] is reported here. 2-(Sec-butylamino)-5-(2-chloro-4-pyridinyl)-1,3,4-thiadiazole (BCPT) is a lead compound for herbicide development. In order to improve its herbicidal activity and study the relationship between chem. structure and bioactivity, an aryl ether moiety was introduced to the sketch. A new series of compounds was synthesized and the structures were confirmed by NMR and elementary anal. A preliminary bioassay showed that all the synthesized compounds showed a poor inhibition rate (0-45%) at 500 mg/L, much weaker than (BCPT) (72%-87%). A chloro-atom on the 2-position of pyridine ring may be indispensable for herbicidal activity.
Nongyaoxue Xuebao published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H8O4, Application of 2-Chloroisonicotinic acid.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics