Ye, Jiao published the artcileSynthesis and Cytotoxicity in Vitro of N-Aryl-4-(tert-butyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amine, Name: 1-(4-Chlorophenyl)thiourea, the publication is Journal of the Chinese Chemical Society (Weinheim, Germany) (2015), 62(7), 627-631, database is CAplus.
A series of novel N-aryl-4-(tert-butyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines I [R = H, 4-Me, 2-F, etc.] were synthesized in a green way. H2O2-NaBr brominating circulatory system was used in the synthesis of the key intermediate in a mild condition. Structures of the target compounds were confirmed by 1H NMR and elemental anal. and tested for their cytotoxicity against two different human cancer cell lines. The cytotoxicity assay revealed that some of the title compounds showed moderate to strong cytotoxic activities. Compound I [R = 3-F3C] was the most potent compound with the IC50 values of 9μM against Hela cells and 15μM against Bel-7402 cells resp.
Journal of the Chinese Chemical Society (Weinheim, Germany) published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C10H16Br3N, Name: 1-(4-Chlorophenyl)thiourea.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics