Zhao, Matthew published the artcileA very concise synthesis of a potent N-(1,3-thiazol-2-yl)pyridin-2-amine KDR kinase inhibitor, Recommanded Product: 2-Chloroisonicotinic acid, the publication is Tetrahedron (2006), 62(6), 1110-1115, database is CAplus.
A very concise synthesis of a potent KDR kinase inhibitor I is described. The synthesis features an exceedingly efficient one-pot preparation of 2-aminothiazole-5-carbonitrile, followed by Pd-Xantphos catalyzed cross-coupling with 2-chloro-4-pyridinecarboxaldehyde. Reductive amination of the resulting aldehyde 2-(4-formylpyridin-2-ylamino)thiazole-5-carbonitrile with N-methyl-1-piperazinecarboxamide afforded the final product I.
Tetrahedron published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C10H18O4, Recommanded Product: 2-Chloroisonicotinic acid.
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