Abd El-Meguid, Eman Ali published the artcileDiscovery of some novel benzothiazole derivatives as VEGFR-2 inhibitors, Quality Control of 21286-54-4, the publication is International Journal of Pharmacy and Technology (2015), 7(3), 10040-10055, database is CAplus.
A series of benzothiazole derivatives were prepared by condensation of 5-amino-1-(4-benzothiazol-2-yl-benzoyl)-1H-pyrazole-4-carbonitrile (1) and/or 5-amino-1-(4-benzothiazol-2-yl-benzoyl)-1H-pyrazole-4-carboxylic acid hydrazide (6) with different electrophilic and nucleophilic reagents. All of the newly synthesized compounds have been evaluated for their potential cytotoxicity against breast cancer cell line (MCF-7); compounds 5c, 8b and 8c are more potent than tamoxifen while compounds 5b and 8a are equipotent to tamoxifen. These results were consistent with percentage of inhibition values against human VEGF compared with control untreated cells.
International Journal of Pharmacy and Technology published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Quality Control of 21286-54-4.
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https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics