Cai, Yingying published the artcileDouble allylic defluorinative alkylation of 1,1-bisnucleophiles with (trifluoromethyl)alkenes: construction of all-carbon quaternary centers, Application In Synthesis of 864725-22-4, the publication is Organic Chemistry Frontiers (2020), 7(10), 1260-1265, database is CAplus.
A double allylic defluorinative alkylation reaction of 1,1-bisnucleophiles such as C6H5CH2 R (R = H, Ph, C(O) C6H5, C(O)OEt, etc.), nitriles R1CH2CN (R1 = Ph, thiophen-2-yl, n-decyl, etc.)and indolin-2-one with (trifluoromethyl)alkenes CH2=C(R2)CF3 (R2 = Ph, naphthalen-2-yl, pyridin-3-yl, etc.) is reported that occurs via the exclusively regioselective SN2 reaction. Various aliphatic nitriles, esters, and indolin-2-one derivatives could serve as 1,1-bisnucleophiles, delivering diverse attractive sym. gem-difluoroalkene substituted products e.g., I in high yields via the construction of all-carbon quaternary centers. Interestingly, the chemoselective SNV reaction between gem-difluoroalkenes and nucleophiles is completely inhibited. The nitrile group might help to stabilize the α-carbanion intermediates.
Organic Chemistry Frontiers published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Application In Synthesis of 864725-22-4.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics