Guo, Ke-Liang published the artcileDesign, Synthesis, and Bioevaluation of Substituted Phenyl Isoxazole Analogues as Herbicide Safeners, Computed Properties of 3919-74-2, the publication is Journal of Agricultural and Food Chemistry (2020), 68(39), 10550-10559, database is CAplus and MEDLINE.
Herbicide safeners enhance herbicide detoxification in crops without affecting target weed sensitivity. To enhance crop tolerance to the toxicity-related stress caused by the herbicide acetochlor (ACT), a new class of substituted Ph isoxazole derivatives was designed by an intermediate derivatization method as herbicide safeners. Microwave-assisted synthesis was used to prepare the Ph isoxazole analogs, and all of the structures were confirmed via IR, 1H NMR, 13C NMR, and HRMS. Compound (I) was further characterized by X-ray diffraction anal. Bioassay results showed that most of the obtained compounds provided varying degrees of safening against ACT-induced injury by increasing the corn growth recovery, glutathione content, and glutathione S-transferase activity. In particular, compound (II) showed excellent safener activity against ACT toxicity, comparable to that of the com. safener benoxacor. Gaussian calculations have been performed and the results indicated that the nucleophilic ability of compound II is higher than that of benoxacor, thus the activity is higher than that of benoxacor. These findings demonstrate that Ph isoxazole derivatives possess great potential for protective management in corn fields.
Journal of Agricultural and Food Chemistry published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Computed Properties of 3919-74-2.
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