Liu, Renxiang published the artcileModified and Scalable Synthesis of N-Tosyl-4-Chlorobenzenesulfonimidoyl Fluoride (SulfoxFluor): Direct Imidation of Sulfinyl Chlorides with Chloramine-T Trihydrate, Category: chlorides-buliding-blocks, the publication is Organic Process Research & Development (2022), 26(2), 380-386, database is CAplus.
A general and practical method for the preparation of N-Tosyl-4-chlorobenzenesulfonimidoyl fluoride (SulfoxFluor) and its adaptation to a large scale was disclosed. Starting from readily available 4-chlorobenzenesulfonyl chloride, chloramine-T trihydrate and potassium fluoride, SulfoxFluor was prepared on a hectogram scale in 63% overall yield with simple purification techniques. The use of chloramine-T trihydrate (instead of anhydrous chloramine-T) was a significant improvement over previous work, which streamlined the process and avoided the risk of explosion during drying or heating. This research not only established a reliable method for the scale-up synthesis of SulfoxFluor but also provided an insight into the imidation of sulfinyl chlorides with chloramine-T in the presence of water.
Organic Process Research & Development published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Category: chlorides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics