Morano, Cain published the artcileMultiple Isotopic Labels for Quantitative Mass Spectrometry, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Analytical Chemistry (Washington, DC, United States) (2008), 80(23), 9298-9309, database is CAplus and MEDLINE.
Quant. mass spectrometry is often performed using isotopically labeled samples. Although the 4-trimethylammonium butyryl (TMAB) labels have many advantages over other isotopic tags, only two forms have previously been synthesized (i.e., a heavy form containing nine deuteriums and a light form without deuterium). In the present report, two addnl. forms containing three and six deuteriums have been synthesized and tested. These addnl. isotopic tags perform identically to the previously reported tags; peptides labeled with the new TMAB reagents coelute from reversed-phase HPLC columns with peptides labeled with the lighter and heavier TMAB reagents. Altogether, these four tags allow for multivariate anal. in a single liquid chromatog./mass spectrometry anal., with each isotopically tagged peptide differing in mass by 3 Da per tag incorporated. The synthetic scheme is described in simple terms so that a biochemist without specific training in organic chem. can perform the synthesis. The interpretation of tandem mass spectrometry data for the TMAB-labeled peptides is also described in more detail. The addnl. TMAB isotopic reagents described here, together with the addnl. description of the synthesis and anal., should allow these labels to be more widely used for proteomics and peptidomics analyses.
Analytical Chemistry (Washington, DC, United States) published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.
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