Nourry, Arnaud published the artcileBRAF inhibitors based on an imidazo[4,5]pyridin-2-one scaffold and a meta substituted middle ring, Application of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Journal of Medicinal Chemistry (2010), 53(5), 1964-1978, database is CAplus and MEDLINE.
We recently reported on the development of a novel series of BRAF inhibitors based on a tripartite A-B-C system characterized by a para-substituted central aromatic core connected to an imidazo[4,5]pyridin-2-one scaffold and a substituted urea linker. Here, we present a new series of BRAF inhibitors in which the central Ph ring connects to the hinge binder and substrate pocket of BRAF with a meta-substitution pattern e. g. I. The optimization of this new scaffold led to the development of low-nanomolar inhibitors that permits the use of a wider range of linkers and terminal C rings while enhancing the selectivity for the BRAF enzyme in comparison to the para series.
Journal of Medicinal Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Application of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.
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