Qin, Yaoguo published the artcileDesign, synthesis and biological activity of novel aphid alarm pheromone analogues containing isonicotinic acid, Name: 2-Chloroisonicotinic acid, the publication is Gaodeng Xuexiao Huaxue Xuebao (2016), 37(11), 1977-1986, database is CAplus.
A series of new aphid alarm pheromone [(E)-β-farnesene, EBF] analogs containing isonicotinic acid was designed based on the principles of connecting sub-structure and bioisosterism. With EBF as a lead compound, 20 EBF analogs were prepared via four steps starting from geraniol. Their structures were confirmed by 1H NMR, 13C NMR, IR and HRMS. The preliminary bioassay suggested that all the analogs showed repellent and aphicidal activities against Myzus persicae (Sulzer). Among them, compounds 7d, 8f and 8n showed good repellent activity with the repellent rate of 62.6%, 62.0% and 61.0% resp.; and the analogs 8a, 8b and 8d exhibited better aphicidal mortality of 73.6%, 81.1% and 70.2% than lead EBF. The primary structure-activity relationship (SAR) anal. indicated that introducing of ester group was favorable to repellent activity while introducing amide was conducive to aphicidal activity. Moreover, N-substituted carbon chain length, number of branched chain as well as aromaticity played roles in repellent activity. This study provides useful clues for further development of novel aphid control agent.
Gaodeng Xuexiao Huaxue Xuebao published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Name: 2-Chloroisonicotinic acid.
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