Vazquez, Alexei published the artcileIdentification of putative calorie restriction mimetics using mammalian gene expression profiles, COA of Formula: C12H15ClO3, the publication is Open Biology (2020), 10(9), 200158, database is CAplus and MEDLINE.
Obesity is a risk factor for cardiovascular diseases, diabetes and cancer. In theory, the obesity problem could be solved by the adherence to a calorie-restricted diet, but that is not generally achieved in practice. An alternative is a pharmacol. approach, using compounds that trigger the same metabolic changes associated with calorie restriction. Here, I expand in the pharmacol. direction by identifying compounds that induce liver gene signature profiles that mimic those induced by calorie restriction. Using gene expression profiles from mice and rat, I identify corticosteroids, PPAR agonists and some antibacterial/antifungal as candidate compounds mimicking the response to calorie restriction in the liver gene signatures.
Open Biology published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C25H47NO8, COA of Formula: C12H15ClO3.
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