Ahmad, Imran published the artcileSyntheses of lipophilic chalcones and their conformationally restricted analogues as antitubercular agents, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(5), 1322-1325, database is CAplus and MEDLINE.
Lipophilic chalcones and their conformationally restricted analogs were synthesized and evaluated for their antitubercular efficacy against Mycobacterium tuberculosis H37Rv strain. Compounds I, II, and III [R = CH2CH2-(piperidin-1-yl), CH2CHMeCH2NMe2] were found to be active MIC at 60, 30, 3.5 and 7.5 μg-mL-1. In vitro cytotoxicity of compounds I, II, III [R = CH2CH2-(piperidin-1-yl), CH2CHMeCH2NMe2] and IV in non-cancerous human epithelial kidney cell line (HEK-293) showed that most active compound III [CH2CH2-(piperidin-1-yl)] was approx. 2.85 times selective towards tubercular vs. healthy cells whereas II was found to be 16 times selective.
Bioorganic & Medicinal Chemistry Letters published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.
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