Al Musaimi, Othman published the artcileCombining solid phase synthesis and chromatographic purification for efficient peptide manufacture, Application In Synthesis of 42074-68-0, the publication is Chimica Oggi (2020), 38(2), 18-21, database is CAplus.
In recent years, peptides have gained an important position in the drug arena for a variety of treatments. Solid-phase peptide synthesis (SPPS) continues to have a significant impact in both R&D as well as in production of com. peptides. The combination of SPPS with reverse-phase (RP) chromatog. separations allowed for the peptides to be purified to levels suitable for drug usage. Thanks to their chem. and phys. stability to high pressure, chems., temperature and oxidising reagents, polystyrene / divinyl benzene (PS/DVB) resins are the main solid support for peptide synthesis as well as being suitable for the chromatog. purification of the peptides by RP and ion exchange (IEX). Depending on the application, the optimal crosslinking changes, as do the optimal particle size, the uniformity in particle size distribution and the porosity of the resin. The characteristics and applications of the PS/DVB resins are explored in this paper for the synthesis and purification of peptides of com. interest.
Chimica Oggi published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Application In Synthesis of 42074-68-0.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics