Fukunaga, Kenji published the artcile2-(2-Phenylmorpholin-4-yl)pyrimidin-4(3H)-ones; A new class of potent, selective and orally active glycogen synthase kinase-3β inhibitors, HPLC of Formula: 6313-54-8, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(24), 6933-6937, database is CAplus and MEDLINE.
A series of 2-(2-phenylmorpholin-4-yl)pyrimidin-4(3H)-ones was synthesized and examined for their inhibitory activity against glycogen synthase kinase-3β (GSK-3β). We found compounds I (R = 4-F (II), 2,6-di-OMe, 2-F-6-Cl) to possess potent in vitro GSK-3β inhibitory activity with good in vitro PK profiles. Compound II demonstrated significant decrease of tau phosphorylation after oral administration in mice and excellent PK profiles.
Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, HPLC of Formula: 6313-54-8.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics