Greguric, Ivan published the artcileDiscovery of [18F]N-(2-(Diethylamino)ethyl)-6-fluoronicotinamide: A Melanoma Positron Emission Tomography Imaging Radiotracer with High Tumor to Body Contrast Ratio and Rapid Renal Clearance, Recommanded Product: 2-Chloroisonicotinic acid, the publication is Journal of Medicinal Chemistry (2009), 52(17), 5299-5302, database is CAplus and MEDLINE.
The high melanoma uptake and rapid body clearance displayed by our series of [123I]iodonicotinamides prompted the development of [18F]N-(2-(diethylamino)ethyl)-6-fluoronicotinamide, a novel radiotracer for PET melanoma imaging. Significantly, unlike fluorobenzoates, [18F]fluorine incorporation on the nicotinamide ring is one step, facile, and high yielding. [18F]N-(2-(diethylamino)ethyl)-6-fluoronicotinamide displayed high tumor uptake, rapid body clearance via predominantly renal excretion, and is currently being evaluated in preclin. studies for progression into clin. trials to assess the responsiveness of therapeutic agents.
Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Recommanded Product: 2-Chloroisonicotinic acid.
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