Grytsai, Oleksandr published the artcileSynthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds, Synthetic Route of 3696-23-9, the publication is Bioorganic Chemistry (2020), 104271, database is CAplus and MEDLINE.
Two series of compounds I (R = H, 2-Cl, 3-Br, etc.; X = CH or N) carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivs I (X = N). The biol. results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series I (R = 3-Br; X = CH or N) on several cell lines tested. Moreover, results point out an antiangiogenic activity of these compds I. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.
Bioorganic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Synthetic Route of 3696-23-9.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics