Jiang, Wanlong published the artcileArylpropionylpiperazines as antagonists of the human melanocortin-4 receptor, Recommanded Product: 3-(2,6-Dichlorophenyl)propanoic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(17), 4674-4678, database is CAplus and MEDLINE.
A series of 3-arylpropionylpiperazines were synthesized as antagonists of the melanocortin-4 receptor. Their potency was increased by replacing the α-Me substituent of the initial lead with a larger s-Bu or i-Bu group. Further potency enhancement was observed when a glycine or β-alanine was incorporated onto the benzylamine. Some compounds demonstrated good potency, moderate selectivity, and oral bioavailability.
Bioorganic & Medicinal Chemistry Letters published new progress about 51656-68-9. 51656-68-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene, name is 3-(2,6-Dichlorophenyl)propanoic acid, and the molecular formula is C9H8Cl2O2, Recommanded Product: 3-(2,6-Dichlorophenyl)propanoic acid.
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