Kumar, Puneet published the artcileMetal-Free Direct Transformation of Aryl Boronic Acid to Primary Amines, COA of Formula: C7H8BClO2, the publication is European Journal of Organic Chemistry (2022), 2022(27), e202200508, database is CAplus.
In this work, a transition-metal free approach for the construction of primary aromatic amines R/R1NH2 (R = 4-chlorophenyl, 2H-1,3-benzodioxol-5-yl, naphthalen-2-yl, etc.)/(R1 = Ph, 4-methylphenyl, 4-hydroxyphenyl, 4-chlorophenyl, 2-cyanophenyl) from aryl boronic acids RB(OH)2 and esters R1Bpin with N-Boc-O-tosylhydroxylamine as an amine surrogate was reported. Bench stable TsONHBoc is easy to use and it produces a non-interfering water-soluble byproduct. The protocol is operative for both electron-rich and electron-deficient aryl boronic acids under acidic conditions, wherein, the former arenes affords a better yield of the desired product. Even, sterically hindered and halogenated substrates are easily amenable under this reaction condition. The current protocol can be scaled up to produce gram-scale primary aromatic amines.
European Journal of Organic Chemistry published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, COA of Formula: C7H8BClO2.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
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