Maurya, Hardesh K. published the artcileStudies on substituted benzo[h]quinazolines, benzo[g]indazoles, pyrazoles, 2,6-diarylpyridines as anti-tubercular agents, Formula: C5H13Cl2N, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(21), 5844-5849, database is CAplus and MEDLINE.
Various substituted 5,6-dihydro-8-methoxybenzo[h]quinazolin-2-amine, 1-(3-(4-alkoxyphenyl)-7-methoxy-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl)ethanone, pyrazole and 2,6-diarylpyridine derivatives have been synthesized in good yields by an efficient methodol. The synthesized compounds were evaluated for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv strain. Compounds I (R = piperidin-1-yl, NMe2), II, and III (R1 = Br, H) exhibited significant anti-tubercular activity at MIC values 50, 100, 50, 25 and 100 μM concentration In vitro cytotoxicity data using THP-1 cells indicated that most active compound III (R1 = Br) is safe as its MIC value is much lower than the cytotoxic value.
Bioorganic & Medicinal Chemistry Letters published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Formula: C5H13Cl2N.
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Chlorides – an overview | ScienceDirect Topics