Mineno, T. published the artcileSolution-phase parallel synthesis of an isoflavone library for the discovery of novel antigiardial agents, Synthetic Route of 33697-81-3, the publication is Combinatorial Chemistry and High Throughput Screening (2002), 5(6), 481-487, database is CAplus and MEDLINE.
Combinatorial chem. has become a dramatically useful tool for the development of new medicinal agents. In the search to discover a novel and effective lead for the treatment of giardiasis, solution-phase synthesis of a library of isoflavone derivatives, e.g. I and II, has been accomplished by reacting the corresponding resorcinols with Ph acetic acid derivatives Of the products screened, several compounds such as I and II exhibited potent antigiardial activity. The details of synthesis, in vitro antigiardial assay, and preliminary structure-activity relationships of these compounds are described.
Combinatorial Chemistry and High Throughput Screening published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Synthetic Route of 33697-81-3.
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