Samet, Alexander V. published the artcileAn Efficient Synthesis of Fused 2-Aryliminothiazolines via a Solvent-Free Cyclopropyliminium Rearrangement, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is ChemistrySelect (2016), 1(10), 2373-2376, database is CAplus.
A series of (Z)-3-aryliminopyrrolo[1,2-c]thiazoles I (Ar = Ph, 4-chlorophenyl, 4-methylphenyl, 4-methoxyphenyl, 3,4,5-trimethoxyphenyl, 3-trifluoromethylphenyl) was synthesized by a base-induced dehydrobromination of 3-arylaminopyrrolo[1,2-c]thiazolium bromides II, which in turn, was obtained via an efficient solvent-free cyclopropyliminium rearrangement of the corresponding 4-cyclopropylthiazole hydrobromides III proceeding in melt at high rate and in excellent yields. Biol. evaluation using phenotypic sea urchin embryo assay showed that 2-arylamino-4-cyclopropylthiazoles IV displayed an antimitotic tubulin-unrelated activity, whereas fused-ring rearrangement products III were proposed to inhibit Ca-Zn-dependent metalloproteases.
ChemistrySelect published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.
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