Shigano, Miyuki published the artcileThe effect of aging on the repeated-dose liver micronucleus assay, SDS of cas: 637-07-0, the publication is Genes and Environment (2021), 43(1), 37, database is CAplus and MEDLINE.
Abstract: Background: The liver micronucleus (MN) assay is an effective and important in vivo test for detecting genotoxic compounds In particular, the repeated-dose liver MN (RDLMN) assay which greatly facilitates incorporation of the liver MN assay into the general toxicity study has been developed. Usefulness of the RDLMN assay was appraised highly in the 7th International Workshops on Genotoxicity Testing (2017 in Tokyo) in that sufficient numbers and types of chems. were studied and easy integration into the general toxicity study is preferred from the 3Rs point of view. However, it was pointed out that it is necessary to evaluate the effect of age at the start of 4-wk repeated administration, since there are limited data, where only those of rats of 6 wk of age at the start of administration are available. In this study, we conducted the 4-wk RDLMN assay using rats of 6 and 8 wk of age (at the start of administration) to investigate the effect of age on the liver MN inducibility. Clofibrate, a weak inducer of liver MN, was used in this study to detect the slight difference in the liver MN induction. Results: The liver MN induced by clofibrate was detected in both rats of 6 and 8 wk of age at the start of administration. However, the liver MN induction was lower in rats of 8 wk of age compared to rats of 6 wk of age at the start of administration. Conclusion: These results suggest that the liver MN inducibility decreases with age. Therefore, we recommend the use of rats of 6 wk of age at start of administration to reliably detect the liver MN induction in the RDLMN assay.
Genes and Environment published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H17NS2, SDS of cas: 637-07-0.
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