Tang, Xu published the artcileSynthesis and bioactivity evaluation of penta-1,4-diene-3-one oxime ether derivatives, Application of 3-Chlorobenzylchloride, the publication is Journal of Pesticide Science (Tokyo, Japan) (2019), 44(4), 242-248, database is CAplus and MEDLINE.
A series of penta-1,4-diene-3-one oxime ether derivatives I (R = 2,4-Cl2C6H3, 4-MeOC6H4, 6-Cl-3-pyridyl, etc.; X = 4-OBn, 2-OBn) were synthesized, and their antiviral and antifungal activities were evaluated. Bioactivity evaluations showed that most target compounds had significant antiviral activity against tobacco mosaic virus (TMV). The synthesized compounds also showed certain inhibitory effects on three plant-pathogenic fungi, but all of them are lower than that of the control drug epoxiconazole. Among them, I (R = 3-FC6H4; X = 4-OBn) was found to have good curative activity against TMV, with an inhibition rate of 64.6%, which was better than that of ribavirin (45.2%). Compound I (R = 6-Cl-3-pyridyl; X = 4-OBn) had a remarkable protective effect against TMV, with an inhibitory rate of 66.9%, which was better than that of ribavirin (61.8%). The inhibitory rate of compound I (R = 4-ClC6H4; X = 2-OBn) in inactivation activity against TMV was 87.0%, which was better than that of ribavirin (77.9%). Further mol. docking studies indicated that compound I (R = 4-ClC6H4; X = 2-OBn) showed strong binding affinities toward the coat protein of tobacco mosaic virus. This result indicates that penta-1,4-diene-3-one oxime ether derivatives can play a significant role in discovering new antiviral agents.
Journal of Pesticide Science (Tokyo, Japan) published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C10H11NO4, Application of 3-Chlorobenzylchloride.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics