Xu, Rong published the artcilePeptide-cross-linked protein-imprinted polymers: easy template removal and excellent imprinting effect, Quality Control of 42074-68-0, the publication is CCS Chemistry (2019), 1(5), 544-552, database is CAplus.
Mol. imprinting of proteins remains a huge challenge because of two major obstacles: difficulty in template removal and low imprinting efficiency. Herein, we propose a new strategy to simultaneously overcome these two challenges by creating molecularly imprinted polymers (MIPs) with nanoscale shape-memorable imprint cavities. These novel MIPs were developed by simply crosslinking the polymers with a peptide cross-linker instead of commonly used cross-linkers. Due to the unique pH-induced helix- coil transition of the peptide cross-linker, adjusting the pH from 5.5 to 7.4 leads to an expansion of the imprint cavities, thus facilitating template removal. Returning the pH back to 5.5 restores the original size and shape of the imprint cavities due to the precise refolding of peptide. A template protein can therefore be readily removed under mild conditions, while simultaneously achieving a significantly improved imprinting effect.
CCS Chemistry published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C7H3IN2O2, Quality Control of 42074-68-0.
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https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics