Yabe, Osamu published the artcileA convergent scale-up synthesis of a HER2/EGFR dual kinase inhibitor, Quality Control of 350-30-1, the publication is Heterocycles (2017), 94(4), 702-715, database is CAplus.
A practical and scalable synthesis of the human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual kinase inhibitor I has been developed. The key features of the process development include convenient construction of the benzisothiazole skeleton directly from com. available materials in high yield, a practical O-demethylation utilizing an ethanethiol or octanethiol/aluminum chloride system without harsh conditions, and development of a more convergent alternative route that coupled two key intermediates in the final step. The novel synthesis allowed the manufacturing process to produce high quality API I (>99% purity (LCAP)) over 7 steps, compared to 9 steps in the original route, without chromatog. purification
Heterocycles published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C10H10O2, Quality Control of 350-30-1.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics