Zawadowski, Teodor published the artcileSynthesis of the 2-[4-hydroxy-7-methyl-5-oxo-5H-furo[3,2-g][1]benzopyran-9-yloxy]acetic and -propionic acid derivatives with expected activity on the circulatory system, Safety of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Acta Poloniae Pharmaceutica (1989), 46(4), 305-12, database is CAplus and MEDLINE.
Etherification of 4,9-didemethylkhellin (I) with ClCH2CO2Et and MeCHClCO2Et in Me2CO containing K2CO3 gave the furobenzopyranyloxyacetic acid derivatives II (R = H, R2 = OEt, R1 = H, Me, resp.), subsequently hydrolyzed with H2SO4 to the corresponding II (R2 = OH, III). II (R = H, R2 = OR3; R1 = H, Me, R3 = 2-(1-piperidinyl)ethyl and 2-(4-morpholinyl)ethyl; R1 = Me, R3 = Me2NCH2CHMe) were prepared in the reaction of III with appropriate R3Cl.HCl in a MeOH-Me2CHOH solution of NaOH. II (R = R1 = H, R2 = NH2, 2-pyridylamino, IV) were prepared by direct etherification of I with the corresponding ClCH2COR2; further reaction with MeI gave II (R = Me, R1 = H, R2 = 2-pyridylamino), and with 2-chloroacetylaminopyridine, the ethers V (R1 = H, R4 = H2NCO and 2-pyridylcarbamoyl). In a similar reaction, 4-demethylkhellin gave V (R1 = R4 = H). IV was comparable with propranolol in antiarrhythmic activity and effect on heart bioelec. action with LD50 as low as 250 mg/kg i.v.
Acta Poloniae Pharmaceutica published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C6H8O6, Safety of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.
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