Design and Synthesis of the First Generation of Dithiolane Thiazolidinedione- and Phenylacetic Acid-Based PPARγ Agonists was written by Chittiboyina, Amar G.;Venkatraman, Meenakshi S.;Mizuno, Cassia S.;Desai, Prashant V.;Patny, Akshay;Benson, Stephen C.;Ho, Christopher I.;Kurtz, Theodore W.;Pershadsingh, Harrihar A.;Avery, Mitchell A.. And the article was included in Journal of Medicinal Chemistry in 2006.Application of 57017-95-5 This article mentions the following:
A series of novel derivatives of potent antioxidant vitamin, α-lipoic acid, and related analogs were designed, synthesized, and evaluated for their PPARγ agonist activities. Compounds I and the water soluble analog II (R = COCH2NH2.HCl) were found to be potent PPARγ agonists. I appeared to have a significant role in improving insulin sensitivity and reducing triglyceride levels in fa/fa rats as well as inhibited proliferation of a variety of normal and neoplastic cultured human cell types. These novel compounds may prove efficacious not only in the treatment of Type 2 diabetes, but also atherosclerosis, prevention of vascular restenosis, and inflammatory skin diseases. In the experiment, the researchers used many compounds, for example, Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5Application of 57017-95-5).
Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 57017-95-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics