Two efficient methods for the preparation of 2-chloro-6-methylbenzoic acid was written by Daniewski, Andrzej R.;Liu, Wen;Puentener, Kurt;Scalone, Michelangelo. And the article was included in Organic Process Research & Development in 2002.Safety of Methyl 2-chloro-6-methylbenzoate This article mentions the following:
Two efficient methods for the preparation of 2-chloro-6-methylbenzoic acid (I) were developed: one based on nucleophilic aromatic substitution and the other based on carbonylation. In the first approach, 2-chloro-6-fluorobenzaldehyde was converted to its butylimine, then treated with 2 equiv of methylmagnesium chloride in THF to give, after hydrolysis, 2-chloro-6-methylbenzaldehyde. Subsequent oxidation of this compound gave I in 85% overall yield. In the second approach, 3-chloro-2-iodotoluene was efficiently carbonylated in methanol to give Me 2-chloro-6-methylbenzoate, which after hydrolysis afforded I in 94% yield (84% yield after recrystallization). The carbomethoxylation proceeded smoothly even at a high substrate-to-Pd ratio of 10 000. Both methods do not require isolation of intermediates and are suitable for the preparation of kilogram quantities of I. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-6-methylbenzoate (cas: 99585-14-5Safety of Methyl 2-chloro-6-methylbenzoate).
Methyl 2-chloro-6-methylbenzoate (cas: 99585-14-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Safety of Methyl 2-chloro-6-methylbenzoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics