Photoredox-Mediated Mono- and Difluorination of Remote Unactivated Methylene C(sp3)-H Bonds of N-Alkyl Sulfonamides was written by Deng, Zhiqiang;Zhao, Zhenxiang;He, Gang;Chen, Gong. And the article was included in Organic Letters in 2021.Computed Properties of C8H9ClO4S This article mentions the following:
A photoredox-mediated δ-C(sp3)-H fluorination of sulfonyl-protected primary alkylamines, e.g., N-cyclododecyl-4-methoxybenzenesulfonamide with Selectfluor is developed. The reaction can proceed in excellent monofluorination selectivity for amine substrates without α substituent. For α-substituted substrates R(CH2)3CH(R1)NHS(O)2-PMP (R = Me, Et, n-Bu; R1 = Me, CH2OBz), slightly modified reaction conditions with two rounds of operation gives the δ,δ-difluorination products RCF2(CH2)2CH(R1)NHS(O)2-PMP in good yield. Mechanistic studies suggest SET oxidation of sulfonamide group directly generates the key sulfonamide N radical intermediate, which triggers a 1,5-HAT process to form the δ alkyl radical. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Computed Properties of C8H9ClO4S).
2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C8H9ClO4S
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics