Second generation specific-enzyme-activated rotaxane propeptides was written by Fernandes, Antony;Viterisi, Aurelien;Aucagne, Vincent;Leigh, David A.;Papot, Sebastien. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2012.Application In Synthesis of 3,3,3-Tris(4-chlorophenyl)propionic acid This article mentions the following:
A [2]rotaxane, in which the peptidic axle is protected from degradation by the macrocyclic sheath and terminated with a novel glycosidase-cleavable stopper, is rendered water-soluble by derivatization with tetra(ethylene glycol) (TetEG) or glucosylated tetra(ethylene glycol) (Glc-TetEG) chains using the CuAAC click’ reaction. The Glc-TetEG-derivatized rotaxane propeptide is >50 000 times more soluble in aqueous media than the parent rotaxane. Activation of the water-soluble rotaxane propeptide with a β-galactosidase efficiently releases the parent peptide. In the experiment, the researchers used many compounds, for example, 3,3,3-Tris(4-chlorophenyl)propionic acid (cas: 2168-06-1Application In Synthesis of 3,3,3-Tris(4-chlorophenyl)propionic acid).
3,3,3-Tris(4-chlorophenyl)propionic acid (cas: 2168-06-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of 3,3,3-Tris(4-chlorophenyl)propionic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics