Synthesis and Antimicrobial Activity of Some Novel [4-(1,2,3-thiadiazol-4-yl)phenoxy]methylene anchored 1,3,4-triazoles and 1,3,4-thiadiazoles was written by Gadhave, A. G.;Gaikar, R. B.;Kuchekar, S. R.;Karale, B. K.. And the article was included in Journal of Heterocyclic Chemistry in 2014.Recommanded Product: 6590-96-1 This article mentions the following:
A series of novel [4-(1,2,3-thiadiazol-4-yl)phenoxy]methylene-anchored 1,3,4-triazoles I (R = H, 2-F, 3-MeO, etc.) and 1,3,4-thiadiazoles II were synthesized from thiosemicarbazides III. The structures of these newly synthesized compounds were confirmed on the basis of IR, 1H-NMR, mass spectral techniques, and elemental anal. The in vitro antimicrobial screenings of the synthesized compounds were carried out against four bacterial pathogens, namely Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa and three fungal pathogens Candida albicans, Aspergillus niger and Aspergillus clavatus, using broth microdilution min. inhibitory concentration method. The compounds I (R = H), II (R = H, 2-F), and III (R = 2-CF3, 3-MeO) exhibited promising antibacterial activity against the tested strains, whereas some compounds were found to be active against one of the tested bacterial strains. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Recommanded Product: 6590-96-1).
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