Synthesis and pharmacological evaluation of carboxamide derivatives as selective serotoninergic 5-HT4 receptor agonists was written by Itoh, Katsuhiko;Kanzaki, Koji;Ikebe, Tsuguo;Kuroita, Takanobu;Tomozane, Hideo;Sonda, Shuji;Sato, Noriko;Haga, Keiichiro;Kawakita, Takeshi. And the article was included in European Journal of Medicinal Chemistry in 1999.Electric Literature of C8H7ClO3 This article mentions the following:
A number of new carboxamide derivatives, e.g. benzoxazinecarboxamides I (n = 0, 1, 2; m = 1, 0) and benzamides II (R = Et, Bu, hexyl, MeSO2NHCH2CH2) were prepared The affinity of these compounds for the serotoninergic 5-HT4 receptor was evaluated by use of radioligand-binding techniques. The agonistic activity was evaluated as the contractile effect of the ascending colon isolated from guinea-pigs. Among these compounds, II (R = MeSO2NHCH2CH2) (III) showed a high affinity for the 5-HT4 receptor. III displayed a higher affinity for 5-HT4 receptors than the other receptors, including 5-HT3 and dopamine D2 receptors. In addition, III was confirmed to be a potent 5-HT4 receptor agonist. An interaction model between III and 5-HT4 receptor was proposed. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Electric Literature of C8H7ClO3).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Electric Literature of C8H7ClO3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics