Synthetic routes to 1,5-diazacyclooctanes via 2,6-dioxo-1,5-diazabicyclo[3.3.1]octanes was written by Kemp, D. S.;Sidell, M. D.;Shortridge, T. J.. And the article was included in Journal of Organic Chemistry in 1979.Recommanded Product: 5335-05-7 This article mentions the following:
Reactions of 3-pyrazolidinones with primary β-chloropropionyl chlorides provide a satisfactory synthetic route to 2,6-dioxo-1,5-diazabicyclo[3.3.0]octanes I (R = H, Me). The corresponding secondary halides cannot be induced to undergo cyclization. The Stetter procedure, reaction of acrylic acid derivatives with hydrazine at 200°, provides an acceptable route to derivatives that bear 4- or 8-alkyl substituents. Reactions of I with NaNH2 in NH3 generate sodium enolates that undergo C-alkylation and C-acylation reactions in high yield. Two new procedures are described for reduction of I to 1,5-diazacyclooctanes, treatment with diborane in refluxing THF and Na-NH3 treatment, followed by reduction by LiAlH4. Reductions of I with Na-NH3 or by sodium naphthalenide in dimethoxyethane generate 2,6-dioxo-1,5-diazacyclooctanes in excellent yield. Convenient preparations of 3,6-dibromohexanoic acid and 2-acetyl-3-chloro-2-methylpropionic acid are described. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Recommanded Product: 5335-05-7).
Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 5335-05-7
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics